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Orange Juice Helps Fight Inflammation, Oxidative Stress: Study

Orange Juice
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According to a new study, 100% orange juice has the potential to assist people to battle inflammation and oxidative stress. The research findings were published in the journal. Advances in Nutrition.’ Despite its limitations, the study found that drinking 100% orange juice decreases interleukin 6, a well-known marker of inflammation, in both healthy and high-risk persons.

Two other inflammatory and oxidative stress markers were also decreased, but the results were not statistically significant. The findings of this study, which was funded by an unrestricted grant from the Florida Department of Citrus, are consistent with a previously published FDOC-funded review that found that hesperidin, the primary bioactive compound found in oranges and 100% orange juice, has anti-inflammatory and anti-oxidant properties.

Chronic inflammation may play a role in the development or progression of certain chronic diseases, such as heart disease and diabetes. “We know that 100% orange juice has a variety of nutrients, such as vitamin C, as well as helpful bioactive chemicals that have the ability to lower inflammation and oxidative stress,” Gail Rampersaud, a registered dietitian with the Florida Department of Citrus, stated.

“According to this analysis, several researchers have found benefits from 100% orange juice, but additional data and big, well-designed studies are needed to draw more clear results. This study will be especially useful as we and others plan future orange juice research “Rampersaud added.

The study looked at research that looked at 100 percent orange juice and inflammation and oxidative stress indicators. The Think Healthy Group and experts from Tufts University and George Mason University collaborated on the study.

A qualitative scoping review of 21 studies with a total of 307 healthy adults and 327 adults at risk for disease; a systematic review of a subset of 16 studies that measured the six most commonly reported biomarkers related to inflammation and oxidative stress in the body; and a meta-analysis of 10 studies with sufficient data.

The researchers also looked at the papers’ overall quality and potential bias. According to the broad scope and systematic reviews, 100% orange juice had either favorable or null (no detrimental) effects on oxidative stress and inflammation.

The researchers emphasized that because the studies had a limited number of participants, a poor level of evidence, and a moderate risk of bias, the conclusions should be regarded with caution.

Obesity, Diabetes are Driving Causes behind Silent Pandemic of Fatty Liver Disease: Study

Obesity

Obesity and diabetes are the main drivers of the silent pandemic of fatty liver disease, according to a new study.

According to a study, people with extensive liver scarring caused by obesity, diabetes, and other diseases die of liver disease. To analyze their outcomes, researchers from Virginia Commonwealth University tracked over 1,700 patients for a median of four years, with some staying for as long as ten years.

Patients with severe fibrosis are more likely to die, according to the researchers, especially after gastrointestinal hemorrhaging or fluid accumulation in the abdomen, as well as increasing impairment of brain function due to liver illness. The findings, which were published in the New England Journal of Medicine, indicated that persons with severely scarred livers are the ones who are most likely to die.

“This is the first clear picture of genuine rates of outcomes in patients with (non-alcoholic fatty liver disease),” said Arun Sanyal, a VCU Health liver disease specialist. “Moreover, the study backs up the American Diabetes Association’s new guidelines to begin screening for liver disease in order to make the screening more mainstream,” he added.

Many people believe that liver damage is caused solely by excessive alcohol usage. Non-alcoholic fatty liver disease, a disorder in which excess fat is deposited in the liver and is more directly associated with obesity and diabetes than alcohol usage, affects a quarter of adults globally. The majority of people are unaware that they have non-alcoholic fatty liver disease or are at high risk of developing it.

If left untreated, the condition can progress to an advanced stage, in which fat deposition in the liver causes inflammation, scarring (fibrosis), and full-blown cirrhosis, which irreversibly damages the liver. Patients are usually diagnosed after their condition has progressed to the point when a transplant is the only choice.

“In the past, many primary care physicians and diabetes specialists believed that because the disease’s roots are in insulin resistance, treating diabetes would solve the problem,” Sanyal said.

“And what this demonstrates is that people with severe fibrosis are dying of liver disease, even in an obese, diabetic society. Simply treating diabetes will not suffice “Added he.

Scientists Identify New Antibody For Covid, Variants: Report

Coronavirus 3D

Scientists from Duke University and the University of North Carolina at Chapel Hill collaborated to find and test an antibody that reduces the severity of infections caused by a range of coronaviruses, including those that cause COVID-19 and the initial SARS sickness.

A team at the Duke Human Vaccine Institute (DHVI) found the antibody, which was then evaluated in animal models at UNC-Chapel Hill. The findings were reported in the journal Science Translational Medicine.

“This antibody has the potential to be therapeutic for the current epidemic,” stated Barton Haynes, M.D., director of DHVI, who was also a co-senior author. “If or when other coronaviruses move from their normal animal hosts to humans, it could be available for future outbreaks.”

Haynes and colleagues at DHVI discovered the antibody by comparing blood samples from a patient who had been infected with the original SARS-CoV-1 virus, which triggered the SARS outbreak in the early 2000s, and a current COVID-19 patient.

They discovered over 1,700 antibodies produced by the immune system to attach to particular locations on viruses and prevent them from infecting cells. Many binding sites are altered or removed when viruses mutate, rendering antibodies ineffective. However, despite alterations, there are often places on the virus that remains unaltered. Antibodies that target these locations were chosen because they have the potential to be extremely effective across diverse viral lineages.

The Duke researchers discovered 50 antibodies that may bind to both the SARS-CoV-1 and SARS-CoV-2 viruses, which cause COVID-19, among the 1,700 antibodies collected from the two people.

Further research revealed that one of the cross-binding antibodies was particularly effective, binding to a variety of animal coronaviruses as well as the two human-infecting diseases.

“This antibody attaches to the coronavirus in a conserved site across several mutations and variants,” Haynes explained. “As a result, it has the ability to destroy a wide variety of coronaviruses.”

After isolating the antibody, the DHVI team turned to UNC experts who specialize in animal coronaviruses. The UNC research, led by co-senior author Ralph S. Baric, Ph.D., an epidemiology professor at the UNC Gillings School of Global Public Health, tested it in mice to see if it might effectively prevent or reduce infections.

It did both, they discovered. The antibody protected mice against SARS, COVID-19 and its variations, such as Delta, and many animal coronaviruses that have the potential to trigger human pandemics when given before they were infected.

“The findings serve as a blueprint for developing universal vaccine tactics that are variant-proof and give wide protection against known and new coronaviruses,” Baric added.

In comparison to mice who were not treated with the antibody after infections, the antibody minimized severe pulmonary symptoms.

“The therapeutic activity even after mice were infected suggests that this could be a treatment used in the current pandemic, but also stockpiled to prevent the spread of a future outbreak or epidemic with a SARS-related virus,” said David Martinez, Ph.D., a postdoctoral researcher in UNC’s Gillings School’s Department of Epidemiology.

“It’s possible that this antibody may be used to prevent SARS-CoV-3 or SARS-CoV-4,” Martinez said.

Can Diabetics Eat Custard Apples?

Custard Apples

The custard apple, or sitaphal, is currently in season. This fruit has a long list of health benefits. The fruit is considered to be healthy for the skin, hair, and eyesight, as well as being high in Vitamin C, Vitamin A, potassium, and magnesium. It is also thought to boost immunity and improve digestion. In an Instagram post, nutritionist Rujuta Diwekar addressed the different myths and truths surrounding the fruit. She posted a photo of fresh custard apples in a basket and talked about the “fears” and “facts” around the fruit.

Myths surrounding the custard apple debunked!
If you have diabetes, stay away from it.

According to Rujuta, it is a frequent misconception that persons with diabetes should avoid Sitaphal. The fruit, on the other hand, has a low glycemic index. Diabetics should also consume local and seasonal fruits.

If you’re overweight, stay away.

People who have gained weight are afraid of eating Sitaphal because they believe it would hurt their bodies. Sitaphal, on the other hand, is a strong source of Vitamin B complex, particularly Vitamin B6, and even helps to reduce bloating, according to Rujuta.

If you have a cardiac condition, stay away from it.

This is usually another Sitaphal-related worry. Rujuta, on the other hand, claimed that this fruit was abundant in minerals like manganese and Vitamin C and that it has anti-aging properties for the heart and circulatory system.

If you have PCOD, stay away from it.

Sitaphal is thought to be harmful to women who suffer from PCOD. Rujuta, on the other hand, claimed that Sitaphal was a good source of iron and that it helped with fatigue, irritation, and enhanced fertility.

Rujuta Diwekar has long advocated for the intake of fruits such as Sitaphal. She previously said that fruits like this assisted in the healing of ulcers and the prevention of acidity. She also mentioned that Sitaphal’s iron content was beneficial to women. She claimed that this fruit increased hemoglobin levels and had bioactive compounds that were anti-obesogenic, anti-diabetic, and anti-cancer.

Here are some more reasons to use this fruit in your winter diet:

Sitaphal is high in micronutrients that are beneficial to your skin. This could be beneficial to folks who suffer from skin problems in the winter. It contains Vitamin A, which is helpful for the eyes and helps the brain work properly. Sitaphal is high in fiber, which is helpful for the body, and it can also help patients with high blood pressure.

Don’t forget to include Sitaphal the next time you’re choosing seasonal fruits.

Disclaimer: This content, including advice, is intended to provide only general information. It is not a substitute for professional medical advice. For more information, always visit a professional or your personal doctor. This information is not the responsibility of Editor99.

Diwali 2021: Easy Ways to Keep up with Your Fitness Routine during Diwali

A woman doing exercise
Photo Credit: https://unsplash.com/

Diwali is less than a week away, and preparations are already on to mark the occasion with traditional zeal. This necessitates splurging on Diwali decorations, purchasing new clothing, and preparing a house party with a rich feast. After all, this is one of those Indian occasions where a variety of sweets and deep-fried dishes are required. It’s natural to be preoccupied with preparations and find it difficult to fit in a workout during the lead-up to the festivities. But don’t panic; we’ve got a few ideas to help you maintain your fitness program even during the Diwali season.
Keep your fitness program from being put on hold by following these simple tips.

1) Dance, Move And Have A Good Time

Festivals are the perfect opportunity to let loose. If you can’t stop yourself from feeling bad about skipping your workout, how about dancing your way into your Diwali celebration? Yes, we mean it in the literal sense. Dance is both a full-body workout and a lot of fun. When calling visitors to invite them to your party, don’t slouch on the couch; keep moving around the house.

2) Make a schedule

Fitness freaks may not need to stick to a rigid daily schedule because they are already in a good routine. During the holidays, though, your schedule may be thrown off. So, it’s best if you plan all of your activities a day ahead of time, allowing time for some exercise.

3) Stick to Your Workout Routine

To be honest, it doesn’t matter how many calories you burn as long as you work out every day, even if it’s for a short period of time. You may not be able to commit much time to your workout during the festival, but there are methods to get up early and exercise for at least 15-20 minutes so that you don’t miss out totally.

4) Bodyweight Workouts

You usually can’t find time to go to the gym during festivities like Diwali. And for a few days, that’s fine. You can switch to various workouts that don’t require any equipment, such as body weight exercises. Crunches, planks, squats, and burpees come to mind. These exercises can be done in the privacy of your own home.

5) Take Long Walks

Because of guests who may have arrived well before Diwali, you may not be able to accomplish anything at home. There is, however, a way out: get up early in the morning and take a long, brisk walk. Alternatively, go for a run/jog to get your heart rate up. Do you want to make sure you keep to your schedule? Make it a group activity by giving your visitors a walking tour of your neighborhood. This will allow you to get some exercise during the day.

A few minutes of exercise can help you stay energized, enhance your mood, and reduce worry, so try these simple ways to stay on track this Diwali.